BORÇLAR KANUNUNUN 484 VE 490. İNCİ MADDELERİ ARASINDAKİ MÜNASEBET

Dmd062331 477..484

The major metabolic pathway of vildagliptin in mice, rats, dogs, and humans is hydrolysis at the cyano group to produce a carboxylic acid metabolite M20.7 (LAY151), whereas the major metabolic enzyme of vildagliptin has not been identified. In the present study, we determined the contribution rate of dipeptidyl peptidase-4 (DPP-4) to the hydrolysis of vildagliptin in the liver. We performed hyd...

Bez nazwy-490

Pns1400063 490..497

Crohn’s disease (CD) and ulcerative colitis (UC) are the two major phenotypes of inflammatory bowel diseases (IBD) which constitute a spectrum of chronic, debilitating diseases characterised by a relapsing inflammation of the intestinal mucosal lining. Evidence from a variety of disciplines implicates the intestinal microbiota in the pathogenesis of idiopathic IBD and their complications, inclu...

Pns1100059 478..484

This paper considers the body of observational evidence examining the association of being breast-fed to cardiovascular risk factors and outcomes in later life, and whether any potentially advantageous findings are causal. Early cardiovascular consequences/correlates of breastfeeding, compared to being formula fed, include markedly higher levels of total blood cholesterol, lower levels of pre-p...

Op-icbj140002 484..496

Synopsis The conquest of land has endowed air-breathers with the capability to utilize ventilation not only to acquire oxygen but also to control blood and intracellular acid-base state. Hypercapnic acidosis (resulting from ventilatory control and/or behavioral choice), thus, has become a universal component of hypometabolic states in air-breathers, with inhibitory and/or protective roles. Here...